Nahar Uddin Barbhuyan, Dubom Tayeng, Neelutpal Gogoi, Lima Patowary, Dipak Chetia, Malita Sarma Barthakur

A prominent class of broad-spectrum antibiotics known as tetracycline works by inhibiting the synthesis of proteins, which prevents the development of bacteria. Tetracycline resistance is typically attributed to one or more of the following causes: ribosomal binding site mutations, acquisition of mobile genetic elements carrying tetracycline-specific resistance genes, and/or chromosomal mutations that increase the expression of intrinsic resistance mechanisms. In this research, our objective is to virtually plan and conduct in-silico experiments to find tetracycline derivatives with inhibitory capability against tetracycline resistance protein. The tetracycline derivatives were screened using the Data Warrior, Discovery Studio, PyRx, and Swiss ADME web tools. Initially, 19 tetracycline derivatives were primarily screened for ADME and toxicity study followed by docking study. Among the tetracycline derivatives, C1, C11, C12, C14, C16, and C17 were found to be the potential drug-like molecules with binding energies of -8.9 kcal/mol, -8.4 kcal/mol, -8.5 kcal/mol, -7.7 kcal/mol, -7.7 kcal/mol, -8.6 kcal/mol respectively. In particular, C1 was predicted to have a better binding affinity towards the target protein than the others.

Sciences of Phytochemistry

Kavitha Karthik Pai, Neethu Mathews, Meenakshi Garg

In this study, we aim to compare the blood glucose control, dietary habits, glycemic load, socio-demographic & lifestyle habits, and anthropometric indices among type 2 diabetics that are consuming oral antidiabetic drug alone versus oral antidiabetic drug with home remedies. A cross-sectional study was undertaken on 300 patients attending OPDs of the Department of Medicine, Kasturba Hospital, Manipal, India, and Goretti Hospital Kallianpura, Udupi, India. The data were subjected to statistical analysis with the SPSS 16 software and dietary analysis was performed with the DietCal software. Out of 300 samples, 127 (42.3%) consumed the antidiabetic drug along with home remedies while 173 (57.7%) participants consumed the antidiabetic drug alone without home remedies. There was no significant difference in glycemic parameters like FBS (0.577NS), PPBS (0.179 NS), HbA1C (0.413NS), and there is no significant difference in the mean glycemic load of the diet between participants of the 2 groups (0.653NS). Dietary habits, socio-demographics, lifestyle habits, and anthropometric indices among the 2 groups do not show a significant difference. Our study revealed the poor control of diet in both groups. Home remedies can give an added benefit if diet and lifestyle modification are followed. Diet and lifestyle modification are very important for glycemic control to prevent long-term complications.

Sciences of Phytochemistry

Ramandeep Singh, Ranjodh Jeet Singh, Satinder Kakar, Jasmeet Kaur

An increased risk of morbidity and mortality is associated with acute pancreatitis (AP) brought on by hypertriglyceridemia (HTG). It is essential to locate the root cause as soon as possible and give those affected the attention they need. The treatment plan includes efforts to lower blood triglyceride levels and supportive care. HTG-induced AP has a similar clinical course to people with other types of acute pancreatitis. However, HTG-induced AP patients have significantly higher clinical severity and associated consequences. As a result, therapy and preventing sickness recurrence depend on a correct diagnosis. At the moment, there are no acknowledged standards for the treatment of HTG-induced AP. Some therapy approaches that effectively decrease serum triglycerides include fibric acids, apheresis/plasmapheresis, insulin, heparin, and omega-3 fatty acids. Following acute phase care, lifestyle modifications, including dietary and drug therapy, are essential for long-term HTG-induced AP control and relapse prevention. To create complete and efficient HTG-induced AP treatment guidelines, more study is required.

Sciences of Pharmacy