Review Open Access

Monday, 9 September 2024

Toxicity and Safety Analysis of Polyhexamethylene Guanidine: A Comprehensive Systematic Review

Ivan Ivanov et al.

Abstract: Polyhexamethylene guanidine (PHMG) is a commonly used disinfectant, but safety concerns have arisen due to poisoning cases. This systematic review assesses the toxicity and safety of PHMG by inhalation, oral administration, skin contact, and ocular contact to determine its potential medical applications and acceptable concentration limits. Searches in PubMed, ScienceDirect, CENTRAL, and CyberLeninka up to January 2024 identified 11 in vitro studies with human cell lines, 28 animal studies, and 1...

Research Article Open Access

Monday, 15 July 2024

A comparative study of in-vivo wound healing properties of Tithonia Diversifolia. A gray crude extracts to Silver Sulphadiazine in Albino Wistar rats.

Jimmy J Daka et al.

Abstract: One species of flowering plant in the Asteraceae family is Tithonia diversifolia A. Gray (T. diversifolia), which grows as a shrub or weed. Significant anti-infective therapeutic characteristics, such as anti-mycobacterial, antifungal, antibacterial, anti-inflammatory, anti-malaria, and anthelmintic effects, have been discovered in the plant's extracts. Ethnic communities have been using the plant extract to cure wounds. They appear to prefer it above conventional treatments in many circumstance...

Research Article Open Access

Thursday, 2 May 2024

Bioactive Compounds of Rosa canina L. and Their Effect on Tumor Necrosis Factor-α and Interleukin-1β Activity in Diabetes-Induced Rats

İlayda Sezin YALÇINKAYA et al.

Abstract: The ethnopharmacological significance of Rosa canina, or dog rose, transcends diverse cultures, with traditional applications in treating various diseases. This study investigates the potential pharmacological application of Rosa canina for diabetes treatment, aiming to assess its antidiabetic properties through in vitro, in vivo, and in silico analyses targeting pro-cytokines. Biochemical profiling utilizing HPLC, and phenolic content analyses were conducted to reveal the antioxidant properties...

Research Article Open Access

Tuesday, 16 April 2024

Chemical profiling of essential oils: Investigations into modulating milk production in dairy cows using in silico methods

İsmihan GÖZE et al.

Abstract: This study aimed to assess the biological and biotherapeutic activities of essential oils derived from the medicinal plants Tanacetum vulgare L., Myrtus communis L. subsp. communis L., and Pimpinella flabellifolia (Boiss.) Benth. Et Hook. ex Drude. Plant samples were systematically collected from the Sivas region of Türkiye. Subsequently, essential oils were extracted using a Clevenger-type apparatus, and their compositions were assessed by gas chromatography–mass spectrometry (GC-MS) analysi...

Review Open Access

Sunday, 25 February 2024

Sterility of Ophthalmic Solutions as a Factor in the Evolution of Primary Packaging for Eye Drops: A Literature Review

Ivan Sergeevich Ivanov et al.

Abstract: Preservatives in eye drops, while not always necessary, can lead to undesirable effects. Developing preservative-free solutions demands special measures for sterility, utilizing multidose or monodose primary packaging. This review explores the merits and drawbacks of these packaging types. A literature search on PubMed, Google Scholar, and EMBASE until December 2023, using MESH terms, yielded 28 studies on multidose ampoules and 24 on monodose packaging. Heterogeneous data revealed advantages an...