Review Open Access

Monday, 12 May 2025

Effect of Gene Polymorphisms on Oral Antidiabetic Drug Response in Patients With Type 2 Diabetes Mellitus

Nur Rahmi Hidayati et al.

Abstract: Diabetes mellitus is currently one of the global health threats. The prevalence and incidence of this disease continue to increase, both in industrialised and developing countries, including Indonesia. There are different types of DM marker gene polymorphisms in each racial group. These genetic variations contribute to the response of oral antidiabetic drugs. This article aims to conduct a narrative review of the influence of gene polymorphisms on oral antidiabetic drug response in patients with...

Research Article Open Access

Friday, 27 December 2024

Development of Chitosan-Based Antimicrobial Hydrogel Incorporating Polyvinylpyrrolidone and PHMG

Ivan Ivanov et al.

Abstract: This study focuses on the development of a chitosan-based hydrogel incorporating polyvinylpyrrolidone and polyhexamethylene guanidine hydrochloride for the rehabilitation of damaged and contaminated skin. The thermal properties of chitosan-containing films were characterized by measuring the glass transition temperature (Tg) using differential scanning calorimetry. Due to challenges in accurately determining the Tg of chitosan from experimental and literature data, an additional method, dynamic ...

Review Open Access

Wednesday, 27 November 2024

A Comprehensive Review on Nutrient Profile and Pharmacological Benefits of Musa paradisiaca

Abdul K. Jaleel et al.

Abstract: The Banana (Musa paradisiaca Linn., Family: Musaceae) is one of the oldest and most widely cultivated fruit plants, dating back to prehistoric times. Bananas are rich in minerals and phytochemicals, contributing to their significant culinary, nutritional, and medicinal properties. This review analyzes 191 peer-reviewed articles published between 1981 and July 2023 to comprehensively assess the health benefits of bananas. Studies highlight their effectiveness in reducing inflammation, can...

Review Open Access

Monday, 9 September 2024

Toxicity and Safety Analysis of Polyhexamethylene Guanidine: A Comprehensive Systematic Review

Ivan Ivanov et al.

Abstract: Polyhexamethylene guanidine (PHMG) is a commonly used disinfectant, but safety concerns have arisen due to poisoning cases. This systematic review assesses the toxicity and safety of PHMG by inhalation, oral administration, skin contact, and ocular contact to determine its potential medical applications and acceptable concentration limits. Searches in PubMed, ScienceDirect, CENTRAL, and CyberLeninka up to January 2024 identified 11 in vitro studies with human cell lines, 28 animal studies, and 1...

Research Article Open Access

Monday, 15 July 2024

A comparative study of in-vivo wound healing properties of Tithonia Diversifolia. A gray crude extracts to Silver Sulphadiazine in Albino Wistar rats.

Jimmy J Daka et al.

Abstract: One species of flowering plant in the Asteraceae family is Tithonia diversifolia A. Gray (T. diversifolia), which grows as a shrub or weed. Significant anti-infective therapeutic characteristics, such as anti-mycobacterial, antifungal, antibacterial, anti-inflammatory, anti-malaria, and anthelmintic effects, have been discovered in the plant's extracts. Ethnic communities have been using the plant extract to cure wounds. They appear to prefer it above conventional treatments in many circumstance...