Latest Publications
Association Between Medication Adherence and Quality of Life Among Tuberculosis Patients: A Study at Permata Kuningan Hospital
Phytochemical Characterization and Evaluation of Antioxidant Activity in Sorghum bicolor Leaves Extracts
Ethnobotany, Phytochemistry, Pharmacology, and Toxicology of Cycas revoluta Thunb.: An Updated Review
Evaluation of Antimicrobial Properties of Passiflora foetida Root Extract Sourced from Rehabilitated Coal Mining Sites in East Kalimantan
The Relationship Between Medication-Related Burden and Therapy Compliance of Hypertension Patients
Self-Medication Practices among University Students during the COVID-19 Pandemic
The Effect of Poloxamer 188 on the Solubility and Dissolution Behaviors of Piroxicam-PEG 4000 Solid Dispersions
Low Glycemic Index Taro Tuber (Colocasia esculenta L.) Flakes as Alternative Food Product for Diabetes Management
Editor's Picks
Discover hand-picked research articles selected by our editorial board for their exceptional contribution to the field.
Sustainable Harvest of Large Pelagic Fish in the Western Sumatra Sea
Large pelagic fish such as tuna, skipjack, and mackerel are key export commodities for fishers at Bungus Oceanic Fishing Port due to high demand and their importance in processed fish products. This study analyzed trends, sustainable potential, and utilization levels of these resources in the western Sumatra Sea. Research conducted from March 17 to April 1, 2023, used a descriptive quantitative survey and literature review, with catch and effort data from 2015 to 2022 processed using Microsoft Excel. Results showed increasing catch trends, with tuna, skipjack, and mackerel projected to reach 723,417 kg, 462,205 kg, and 706,592 kg by 2025, respectively. The Maximum Sustainable Yield (MSY) estimates were 532,728 kg/year for tuna, 1,047,319 kg/year for skipjack, and 10,445,616 kg/year for mackerel. On average, the utilization rate was 37%, with a fishing effort rate of 24%, both categorized as moderate. Although tuna catches exceeded the MSY in 2021 (109.55% utilization), average exploitation across species remained sustainable. These findings suggest current fishing practices have not yet surpassed ecological limits, providing room for controlled increases in fishing efforts to maximize yields while maintaining ecological balance.
NLP Analysis of Mannan-Based Drug Delivery Trends
Mannan, a polysaccharide derived from various sources, has gained attention for its biocompatibility and potential in targeted drug delivery. Since its initial use in 1911 as an ointment base, mannan has been applied in cancer therapy, vaccine development, and as an antimicrobial agent. However, research is still largely dominated by in vitro and preclinical studies, with few clinical trials conducted to date. This study aims to provide an overview of mannan's advancements, its uses in drug delivery, the mechanisms involved, the research gaps, and the underexplored areas with significant potential. This study analyzed 321 peer-reviewed articles selected from Scopus (2000-2024), employing natural language (NLP) and bibliometric mapping to identify key materials, application areas, and research trends. Mannan’s flexible molecular structure allows for copolymerization with polymers such as chitosan, alginate, polyacrylate, and polycaprolactione, enabling improved targeting, mucoadhesion, and controlled drug release. Chitosan emerged as the most frequently used co-polymer, particularly in nanogel formulations for cancer and inflammatory diseases. Keyword impact analysis also revealed growing interest in mannans role in post-COVID-19 cytokine storm mitigation and vaccine enhancement, despite limited representation in clinical pipelines. Optimization of polymer ratios, crosslinker use and formulation strategies, remains essential to improving translational outcomes. Future research should also focus on clinical trials to demonstrate its effectiveness. In conclusion, this study underscores mannans role as promising biomaterial for next-generation drug delivery systems, while identifying gaps in clinical validation, mechanistic insight, methodological consistency. To advance toward commercial and clinical applications, future research should integrate machine learning models for predicting formulation parameters and drug release profiles. This findings offer a roadmap for the design, standardization, and eventual commercialization of mannan-based delivery platforms.
Effect of Gene Polymorphisms on Oral Antidiabetic Drug Response in Patients With Type 2 Diabetes Mellitus
Diabetes mellitus is currently one of the global health threats. The prevalence and incidence of this disease continue to increase, both in industrialised and developing countries, including Indonesia. There are different types of DM marker gene polymorphisms in each racial group. These genetic variations contribute to the response of oral antidiabetic drugs. This article aims to conduct a narrative review of the influence of gene polymorphisms on oral antidiabetic drug response in patients with type 2 diabetes mellitus. Article searches were conducted in PubMed, Scopus, Google Scholar, and Wiley published from 2014 to 2024. From the screening, 30 articles met the criteria. The articles reported various gene polymorphisms associated with the efficacy of oral antidiabetic therapy in patients with type 2 diabetes mellitus. In patients with type 2 diabetes mellitus with certain gene variations, there was no significant decrease in HbA1c values after taking medication. Gene polymorphisms may affect the pharmacokinetics of oral antidiabetics and therapeutic response in patients with type 2 diabetes.
Development of Chitosan-Based Antimicrobial Hydrogel Incorporating Polyvinylpyrrolidone and PHMG
This study focuses on the development of a chitosan-based hydrogel incorporating polyvinylpyrrolidone and polyhexamethylene guanidine hydrochloride for the rehabilitation of damaged and contaminated skin. The thermal properties of chitosan-containing films were characterized by measuring the glass transition temperature (Tg) using differential scanning calorimetry. Due to challenges in accurately determining the Tg of chitosan from experimental and literature data, an additional method, dynamic mechanical analysis, was employed. Using the literature value for the Tg of polyhexamethylene guanidine hydrochloride, the transitions of the components were determined. The estimated sorption capacity of the developed hydrogel showed that the inclusion of polyhexamethylene guanidine hydrochloride reduced the moisture content, as expected. However, the overall behavior of the hydrogels remained similar. Vapor permeability, an important factor in wound healing, was also evaluated. Antimicrobial testing revealed no activity for the chitosan control sample despite some reports in the literature, while the samples containing polyhexamethylene guanidine hydrochloride exhibited superior antimicrobial efficacy. These findings suggest that the incorporation of polyhexamethylene guanidine hydrochloride and polyvinylpyrrolidone significantly enhances both the mechanical strength and antimicrobial potential of chitosan-based hydrogels, positioning them as promising candidates for the treatment of contaminated wounds.
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