Sciences of Pharmacy

Sciences of Pharmacy

Articles Published in Volume 1 Issue 2

Jessy Amalia Pratama Beta, Octaviana Maria Simbolon, Maria Elvina Tresia Butar-butar. Antibiotic Use in Diabetes Mellitus Patients with Gangrene at Abdoel Wahab Sjahranie Samarinda Hospital. Sciences of Pharmacy. 2022; 1(2):33-38.

Abstract: Gangrene is one of the complications of diabetes mellitus. Along with the rising prevalence of diabetes mellitus (DM), the prevalence of gangrene and necrosis manifestations such as ulcers and infections will ascend. The selection of appropriate antibiotics is critical in infection therapy. Inapprop Show more...
Abstract: Gangrene is one of the complications of diabetes mellitus. Along with the rising prevalence of diabetes mellitus (DM), the prevalence of gangrene and necrosis manifestations such as ulcers and infections will ascend. The selection of appropriate antibiotics is critical in infection therapy. Inappropriate use of antibiotics will result in antibiotic resistance. Therefore, this research aims to overview demographic, clinical characteristics, antibiotic use profiles, and antibiotic-related problems for DM patients with gangrene at the Abdoel Wahab Sjahranie Samarinda Hospital. The study was retrospective research and was conducted in July-December 2021. Twenty-one patients met the inclusion criteria, and demographic data showed that most patients were men 57% (n=11), and most age was 39-59 years (57%, n=12). The longest period of suffering from gangrene was 6-10 years (14%, n=3). The most common length of hospitalization was 8-14 days, as reported by 52 percent (n=11) of patients, and the most common duration of antibiotic use was ten days, as reported by 86 percent (n=18) of patients. A single-used antibiotic was ceftriaxone (19%, n=4) patients. The most used antibiotic combination was ceftriaxone and metronidazole (81%, n=17). Fourteen patients used antibiotics appropriately in dosage, route, and frequency. Four patients were unsuitable for the benefit of antibiotics in terms of antibiotic type, and three patients were unsuitable for antibiotic use in terms of duration of administration. Show less...

Diabetes wound healing Gangrene Antibiotics resistance Antibiotic-related problems Drug-related problem

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Ainun Jariya, Andi Atirah Masyita, Ririen Hardani. Knowledge Level of OTC and OTC Limited Drugs Use for Self-medication in the Community of Tondo Village, Mantikulore District, Central Sulawesi, Indonesia. Sciences of Pharmacy. 2022; 1(2):25-32.

Abstract: Self-medication is treatment without a doctor's prescription, based on the 2022 BPS, the percentage of self-medication for the people of Central Sulawesi in 2021 is 85.85%. The purpose of the study was to determine the characteristics of the community who did self-medication, minor illnesses that we Show more...
Abstract: Self-medication is treatment without a doctor's prescription, based on the 2022 BPS, the percentage of self-medication for the people of Central Sulawesi in 2021 is 85.85%. The purpose of the study was to determine the characteristics of the community who did self-medication, minor illnesses that were treated with self-medication, the profile of over-the-counter (OTC) and OTC limited medicines for self-medication and the level of knowledge of these medicines use for self-medication in the community of Tondo Village. This type of research was descriptive with a sample of 386 respondents who were taken using purposive sampling. Time of data collection during August – November 2021. Based on the results, the respondents characteristics were female (52.3%) aged 26-35 (24.4%), household work (31.1%), history of high school education (46.4%). Minor illnesses that were treated using self-medication were fever (15.54%), ulcer (7.46%), cough (15.54%), flu (18.91%), diarrhea (2.85%), headache (1 .30%), and allergy (0.78%). The profiles of OTC and OTC limited drugs are limited to paracetamol for fever (33.16%), antacids for ulcers (75.70%), Komix® for coughs (28.8%), Mixagrib® for flu (36.99%), Entrostop® for diarrhea (70,00%), Ibuprofen for headaches (100%), and CTM for allergies (100%). Number of pharmacy or drug store was 61.46%. The selection of drugs were based on experience and personal/family usage history (84.46%), and the reason for self-medication was to save treatment costs (47.15%). The level of knowledge on the use of OTC and OTC limited drugs was categorized as good (75.09%). Based on the findings, we can conclude that the level of knowledge on the use of OTC and OTC limited drugs for self-medication of Tondo people is categorized as good. Show less...

Over-the-counter medicine (OTC) Self-medication Drug use knowledge

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Dwi Ayu Riningsih, Octaviana Maria Simbolon, Maria Elvina Tresia Butar-butar. Profile of Intravenous Preparation Mixing in Patients at the Regional General Hospital's Intensive Care Unit Abdoel Wahab Sjahranie Samarinda. Sciences of Pharmacy. 2022; 1(2):18-24.

Abstract: Compatibility is one of the quality characteristics of intravenous (IV) preparations that influences the effectiveness of patient therapy in the Intensive Care Unit (ICU). The purpose of this study was to determine the compatibility profile of IV medication formulations given to ICU patients. This p Show more...
Abstract: Compatibility is one of the quality characteristics of intravenous (IV) preparations that influences the effectiveness of patient therapy in the Intensive Care Unit (ICU). The purpose of this study was to determine the compatibility profile of IV medication formulations given to ICU patients. This prospective observational research was undertaken on patients in the ICU of a private hospital in Samarinda. The data on intravenous combination of drugs were compared in this study utilizing the ASHP Injectable Drug Information literature 21st edition, Injectable drug guide, and Manual Book. Injectable Drug Mixing was published in 2009 as a resource for determining the compatibility of intravenous formulations. Using certain criteria, combinations of intravenous medicines and their solvents are classed as compatible (C), incompatible (I), and unknown (U). The ICU had 25 patients, 15 of whom were male and 10 of them were female. There is no mixing of drug compounds containing incompatible solvents. All drugs were carried out with 100% compatible solvents. The limited information related to the compatibility and stability of these intravenous preparations encourages continuous monitoring of the patient's condition and drug levels. Show less...

Intravenous preparation compatibility Intensive Care Unit Intravenous admixture Compatibility study

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Christy Putri Tari, Octaviana Maria Simbolon, Maria Elvina Tresia Butar-butar. Evaluation of Mixed Intravenous Preparation in Patients at the Hospital "X" Samarinda's Intensive Care Unit (ICU). Sciences of Pharmacy. 2022; 1(2):10-17.

Abstract: Mixing intravenous preparation especially in patients intensive care unit (ICU) at the hospital requiring special attention relating to their higher had medication errors, as nosocomial infection and incompatibility drugs. Things that need to be considered in mixing sterile preparations, namely comp Show more...
Abstract: Mixing intravenous preparation especially in patients intensive care unit (ICU) at the hospital requiring special attention relating to their higher had medication errors, as nosocomial infection and incompatibility drugs. Things that need to be considered in mixing sterile preparations, namely compounding personnel, facilities and infrastructure and the process of mixing sterile preparations. This study aims to calculate the percentage of suitability for the mixing process for intravenous preparations based on the Basic Guidelines for Dispensing Sterile Preparations, Guidelines for Injectable and Cytostatic Drugs in 2009 and the Handbook of Injectable Drugs Edition 16th for Intensive Care Unit (ICU) patients at the hospital “X” Samarinda. The research is descriptive research using sheets observational data collection. The subject of research is do mixing, facilities, and infrastructure as well as mixing procedure. The results of observations as many 215 processes of mixing intravenous preparations observed in the ICU showed that 100% of compounding personnel were carried out by nurses, and 100% of infrastructure did not have a clean room, LAF, and pass box, 53% carried out the mixing process according to procedures, and physical quality tests. drug preparations are 100% in accordance with the Handbook of Injectable Drugs Edition 16th, namely the preparations produced are clear and free of foreign particles. Show less...

Mixed intravenous preparation Intensive Care Unit (ICU) Sterile dosage Drug physical quality

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Recky Patala, Viani Anggi. Pharmacophore Modeling and Molecular Docking of Flavonoid Derivatives in Abelmoschus manihot Against Human Estrogen Receptor Alpha of Breast Cancer. Sciences of Pharmacy. 2022; 1(2):1-9.

Abstract: Tamoxifen is the most commonly used anti-estrogen adjuvant therapy for estrogen receptor-positive breast cancer. However, it is associated with an increased risk of some serious side effects, such as uterine cancer, stroke, and pulmonary embolism. The flavonoid compounds in the leaves of A. manihot Show more...
Abstract: Tamoxifen is the most commonly used anti-estrogen adjuvant therapy for estrogen receptor-positive breast cancer. However, it is associated with an increased risk of some serious side effects, such as uterine cancer, stroke, and pulmonary embolism. The flavonoid compounds in the leaves of A. manihot inhibited the growth of 4T1 breast cancer cells at a CTC50 concentration of 185.06 μg/ml. Therefore, this study aims to examine the molecular interactions and pharmacophore modeling based on the interaction of 4-OHT with human ER, followed by the molecular docking of the flavonoid derivatives with human ERα. The molecular docking simulations and 3D structure-based pharmacophore models were used to identify the molecular interactions of flavonoid derivatives in A. manihot on estrogen receptors (ERα) (PDB ID: 3ERT). The results showed that the binding energies of the flavonoid derivatives in isorhamnetin and isoquercitrin were -8.68 kcal/mol and -8.75 kcal/mol, respectively. This compound also interacted with Arg394 and Glu353 important amino acid residues in the ERα-binding pocket. Meanwhile, the pharmacophore fit scores of isorhamnetin and isoquercitrin were 82.36% and 84.91%, respectively. The flavonoid derivatives in A. manihot had pharmacophore fit resulting from the 4-OHT complex with ER, and therefore they had potential as ERα antagonists. Out of the 10 flavonoid derivatives, isorhamnetin and isoquercitrin showed the best docking scores and could be used as candidates for new anti-breast cancer drugs with antagonistic activity against ERα. Show less...

Abelmoschus manihot Estrogen Receptor Alpha Molecular Docking Pharmacophore

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