Sciences of Pharmacy Archives (Volume 4 Issue 3)

Grace Faskarina Sembiring, Sahat Saragi, Rafrini Amyulianthy. Improving Hospital Pharmacy Service Quality Using Lean Management Principles. Sciences of Pharmacy. 2025; 4(3):186-196.

Abstract: Optimal pharmaceutical services are a crucial factor in enhancing the overall quality of hospital care. Pharmacy installations often face challenges such as non-compliance with standard operating procedures, prolonged service waiting times, and inefficiencies in drug stock management. This study aim Show more...

Abstract: Optimal pharmaceutical services are a crucial factor in enhancing the overall quality of hospital care. Pharmacy installations often face challenges such as non-compliance with standard operating procedures, prolonged service waiting times, and inefficiencies in drug stock management. This study aims to analyze improvements in pharmaceutical service processes through the application of Lean Management, with the goal of enhancing effectiveness, efficiency, and patient satisfaction. This research employed a qualitative descriptive approach using observations, interviews, and secondary data analysis. The setting of the study was the Pharmacy Installation at RSIA Viola Bekasi. The implementation of Lean Management was initiated and conceptualized in collaboration with the researchers and hospital management. Prior to the intervention, the average waiting time for compounded prescriptions ranged from 30 to 45 minutes, while non-compounded prescriptions took approximately 15 to 20 minutes. After the Lean intervention, these waiting times decreased significantly to an average of 20.17 minutes for compounded prescriptions and 6.5 minutes for non-compounded prescriptions—indicating an efficiency improvement of approximately 33% to 68%, depending on the type of service. The application of Lean Management also led to notable reductions in waste, improved service flow, and more effective drug inventory management through the adoption of Just-in-Time (JIT) and First Expired, First Out (FEFO) systems. These changes enhanced both the operational performance and responsiveness of the pharmacy unit. In conclusion, the findings confirm that Lean Management is an effective strategy for improving pharmaceutical service quality. By systematically addressing inefficiencies and streamlining processes, Lean principles not only support patient-centered care but also contribute to broader hospital service optimization. This study also adds to the Lean Management literature by offering contextual evidence from a maternal and child healthcare facility in the Indonesian hospital setting Show less...

Lean management Effectiveness Efficiency Service Quality Pharmaceutical Services

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Minda Sari Lubis, Ziza Putri Aisyia Fauzi, Sri Harti Dewi, Zulmai Rani, Rafita Yuniarti. Liquid Soap with Pineapple Hump Extract and Nanoformulation Against Staphylococcus aureus . Sciences of Pharmacy. 2025; 4(3):197-204.

Abstract: Staphylococcus aureus is a Gram-positive bacterium that frequently causes skin infections and can become resistant to various antibiotics. Pineapple (Ananas comosus) waste, particularly the hump, contains active compounds such as bromelain, saponins, and flavonoids with known antibacterial pro Show more...

Abstract: Staphylococcus aureus is a Gram-positive bacterium that frequently causes skin infections and can become resistant to various antibiotics. Pineapple (Ananas comosus) waste, particularly the hump, contains active compounds such as bromelain, saponins, and flavonoids with known antibacterial properties. This study aimed to determine the antibacterial potential of liquid soap formulated with extract and nanoextract of pineapple hump against S. aureus. The pineapple hump was extracted using maceration with 96% ethanol, followed by nanoparticle formulation using a high-speed homogenization method. Liquid soap was made with three formulas, one formula contains a concentration of 12.5% extract and two formulas contain 1.25% nanoextract of pineapple hump. Antibacterial activity was evaluated using the disc diffusion method, and the diameter of the inhibition zones was measured. Results showed that all tested concentrations produced antibacterial activity, with the 12.5% concentration (Formula 1) exhibiting the highest inhibition zone (23.2 mm), followed by 1.25% nanoextract nano liquid soap (18.41 mm) (Formula 3) and 1.25% nanoextract liquid soap (14.53 mm) (Formula 2). The positive control (Dettol Handwash) produced a larger inhibition zone (20.08 mm). Data analysis using one-way ANOVA revealed significant differences for each formula, with a p-value of less than 0.05. These findings indicate that nanoextract of pineapple hump formulated in liquid soap has potential as a natural antibacterial agent against S. aureus. Show less...

Ananas comosus Antibacterial Pineapple hump Nanoextract Staphylococcus aureus Liquid soap

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Yusransyah Yusransyah, Ihda Nurhikmah, Zahra Citra Maharani, Sofi Nurmay Stiani, Afifah Nur Shobah, Baha Udin. Pharmacoeconomic Analysis of Drugs Used in Chronic Outpatients at Berkah Pandeglang Regional Hospital. Sciences of Pharmacy. 2025; 4(3):171-179.

Abstract: Hypertension and type 2 diabetes mellitus (T2DM) are chronic conditions requiring long-term pharmacotherapy, placing significant financial pressure on patients and healthcare systems. Drug selection should prioritize both clinical efficacy and cost-efficiency, particularly in resource-limited settin Show more...

Abstract: Hypertension and type 2 diabetes mellitus (T2DM) are chronic conditions requiring long-term pharmacotherapy, placing significant financial pressure on patients and healthcare systems. Drug selection should prioritize both clinical efficacy and cost-efficiency, particularly in resource-limited settings. This study conducted a pharmacoeconomic evaluation of commonly used therapies at RSUD Berkah Pandeglang using a retrospective, non-experimental design. Data were collected from 2023 outpatient records and analyzed from the hospital’s perspective. Cost-effectiveness was assessed using the Average Cost-Effectiveness Ratio (ACER). For hypertension, amlodipine (n=20) had a lower ACER (Rp 283,913) than candesartan (n=15; Rp 883,000), indicating higher cost-effectiveness. In T2DM patients, metformin (n=25) was more cost-effective (ACER: Rp 317,746.75) than glimepiride (n=25; ACER: Rp 607,148.84). These findings support prioritizing amlodipine and metformin as first-line treatments in similar public healthcare settings to improve therapeutic outcomes while managing costs. Show less...

Pharmacoeconomic analysis Cost-effectiveness of hypertension drugs Cost-effectiveness of diabetes medication Amlodipine vs candesartan Metformin vs glimepiride Cost-effective treatment for hypertension Cost-effective therapy for type 2 diabetes ACER pharmacoeconomics

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Fachrurrazi Al Ansori, Rauza Sukma Rita, Almurdi Almurdi. Protective Effects of Java Plum (Syzygium cumini) Leaf Extract on Serum Biomarkers in Lead-Exposed Rats. Sciences of Pharmacy. 2025; 4(3):180-185.

Abstract: Lead (Pb), a heavy metal recognized as a hazardous environmental toxin, triggers oxidative stress by catalyzing oxidation reactions that produce free radicals, ultimately leading to cell death. Liver cell damage due to lead can decrease serum albumin levels, while kidney damage can increase serum ur Show more...

Abstract: Lead (Pb), a heavy metal recognized as a hazardous environmental toxin, triggers oxidative stress by catalyzing oxidation reactions that produce free radicals, ultimately leading to cell death. Liver cell damage due to lead can decrease serum albumin levels, while kidney damage can increase serum uric acid levels. To counteract this oxidative stress, the intake of exogenous antioxidants is necessary. Java plum (Syzygium cumini) leaves are abundant in natural antioxidants, including flavonoids and phenolic compounds. The compounds possess antioxidant potential by scavenging free radicals. The purpose of this study was to determine the effects of an extract of S. cumini on serum albumin and uric acid in rats induced with lead acetate. All treatments lasted 30 days. Testing for serum albumin and uric acid was performed using the DiaSys method. One-way ANOVA followed by the Bonferroni post hoc test revealed significant differences (p < 0.05) in serum albumin levels among the groups: the normal group (4.13 g/dL), the positive control (2.86 g/dL), and the treatment group (3.93 g/dL). Similarly, significant differences were observed in serum uric acid levels: the normal group (1.47 mg/dL), the positive control (3.14 mg/dL), and the treatment group (1.64 mg/dL). These results indicate that S. cumini extract helps mitigate the adverse effects of lead exposure on serum albumin and uric acid levels in rats. A p-value of less than 0.05 indicates that the observed differences are statistically significant and unlikely due to chance. Show less...

Lead poisoning Oxidative damage Medicinal plants Syzygium cumini extract

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Reza Pratama, Daisy Jane Cabellon-Semense, Lela Sulastri, Mia Arifka, Yayan Rizikiyan. NLP Analysis of Mannan-Based Drug Delivery Trends. Sciences of Pharmacy. 2025; 4(3):151-170.

Abstract: Mannan, a polysaccharide derived from various sources, has gained attention for its biocompatibility and potential in targeted drug delivery. Since its initial use in 1911 as an ointment base, mannan has been applied in cancer therapy, vaccine development, and as an antimicrobial agent. However, res Show more...

Abstract: Mannan, a polysaccharide derived from various sources, has gained attention for its biocompatibility and potential in targeted drug delivery. Since its initial use in 1911 as an ointment base, mannan has been applied in cancer therapy, vaccine development, and as an antimicrobial agent. However, research is still largely dominated by in vitro and preclinical studies, with few clinical trials conducted to date. This study aims to provide an overview of mannan's advancements, its uses in drug delivery, the mechanisms involved, the research gaps, and the underexplored areas with significant potential. This study analyzed 321 peer-reviewed articles selected from Scopus (2000-2024), employing natural language (NLP) and bibliometric mapping to identify key materials, application areas, and research trends. Mannan’s flexible molecular structure allows for copolymerization with polymers such as chitosan, alginate, polyacrylate, and polycaprolactione, enabling improved targeting, mucoadhesion, and controlled drug release. Chitosan emerged as the most frequently used co-polymer, particularly in nanogel formulations for cancer and inflammatory diseases. Keyword impact analysis also revealed growing interest in mannans role in post-COVID-19 cytokine storm mitigation and vaccine enhancement, despite limited representation in clinical pipelines. Optimization of polymer ratios, crosslinker use and formulation strategies, remains essential to improving translational outcomes. Future research should also focus on clinical trials to demonstrate its effectiveness. In conclusion, this study underscores mannans role as promising biomaterial for next-generation drug delivery systems, while identifying gaps in clinical validation, mechanistic insight, methodological consistency. To advance toward commercial and clinical applications, future research should integrate machine learning models for predicting formulation parameters and drug release profiles. This findings offer a roadmap for the design, standardization, and eventual commercialization of mannan-based delivery platforms. Show less...

Mannan Nanocarrier Targeted delivery Chitosan Immunotherapy Cytokine storm Clinical translation Machine learning

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Lela Sulastri, Nining Sugihartini, Nuri Ari Efiana. Pometia pinnata in Pharmaceutical Research: Bioactivity, Mechanisms, and Formulation Prospects. Sciences of Pharmacy. 2025; 4(3):133-150.

Abstract: A literature review was conducted to gather information on the pharmacological properties and pharmaceutical dosage forms made from the Matoa plant (Pometia pinnata). The review aimed to provide a basis for further research and explore the potential of Matoa in the health sector. The method involved Show more...

Abstract: A literature review was conducted to gather information on the pharmacological properties and pharmaceutical dosage forms made from the Matoa plant (Pometia pinnata). The review aimed to provide a basis for further research and explore the potential of Matoa in the health sector. The method involved searching electronic media platforms, specifically Google Scholar, PubMed, and Open Knowledge Maps, using targeted keywords such as "Matoa,” "Pometia pinnata,” "Matoa preparation formulation,” "Pometia pinnata pharmaceutical preparation,” "Preparation of Pometia pinnata," and "Function of Pometia pinnata." The inclusion criteria included original research, full-text articles, and open-access journals, all published within the last 10 years, in both Indonesian and English. After screening, 64 articles were identified from the 185 search results. The review revealed that various parts of the Matoa plant, including leaves, fruit, stem bark, fruit peel, and roots, possess pharmacological properties such as antibacterial, analgesic, antioxidant, sunscreen, anticancer, antidiarrheal, anti-HIV, anti-obesity, diuretic, nephrotoxic, and antihypertensive activities. Additionally, various pharmaceutical dosage forms containing Matoa were studied, including topical preparations such as lotions, creams, liquid soap, and body scrubs, as well as oral preparations like effervescent powders, herbal drinks, and jelly candies. The review suggests that numerous research opportunities remain to further explore the potential of Matoa in the pharmaceutical and healthcare fields, as well as to develop innovative dosage forms for optimal results. Show less...

Matoa pharmacology Matoa plant medicinal uses Matoa bioactivity Traditional plant-based medicine Ethnopharmacology of matoa

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Syilvi Adini, Shirly Kumala, Siswa Setyahadi. Antibacterial Activity of Kecombrang (Etlingera elatior) Stems Against Skin Infection-Causing Bacteria. Sciences of Pharmacy. 2025; 4(3):127-132.

Abstract: Skin infections caused by Staphylococcus aureus, Staphylococcus epidermidis, and Propionibacterium acnes often exhibit resistance to conventional treatments. This issue has led to the exploration of medical plants, such as kecombrang stems (Etlingera elatior), which are known for their antibacterial Show more...

Abstract: Skin infections caused by Staphylococcus aureus, Staphylococcus epidermidis, and Propionibacterium acnes often exhibit resistance to conventional treatments. This issue has led to the exploration of medical plants, such as kecombrang stems (Etlingera elatior), which are known for their antibacterial properties. This study aimed to evaluate the antibacterial activity of kecombrang stem and to identify its active compounds. The methanolic extract of kecombrang stems was tested against the three bacteria using the disc diffusion method at concentrations of 80%, 40%, and 20%. The Minimum Inhibitory Concentration (MIC) was determined using the microdilution method and an ELISA reader. TLC-Bioautography was employed to identify the antibacterial compounds present in the extract. The methanol extract of kecombrang stems exhibited antibacterial activity against S. aureus, S. epidermidis, and P. acnes, with an inhibition zone diameter ranging from 9.23 ± 0.472 to 25.53 ± 0.378 mm. The MIC results showed that the minimum concentration of 78.12 ppm could inhibit the growth of S. aureus by 33.74%, S. epidermidis by 14.45%, and P. acnes by 3.5%. The results of TLC Bioautography analysis indicate that flavonoids exhibit antibacterial properties. The kecombrang stem has the potential to serve as an antibacterial agent against bacteria that cause skin infections. Show less...

Antibacterial activity Kecombrang stems Microbial Inhibitory Concentration (MIC) TLC-Bioautography

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Hasniah Hasniah, Dyah Aryani Perwitasari, Woro Supadmi. Long-Term Protection After Primary Hepatitis B Vaccination: A Systematic Review. Sciences of Pharmacy. 2025; 4(3):103-108.

Abstract: Vaccination has proven effective in preventing HBV transmission and reducing related health burdens. This study aimed to systematically review the long-term effectiveness of the hepatitis B vaccine following primary vaccination. A literature search was conducted using PubMed, ProQuest, and the Cochr Show more...

Abstract: Vaccination has proven effective in preventing HBV transmission and reducing related health burdens. This study aimed to systematically review the long-term effectiveness of the hepatitis B vaccine following primary vaccination. A literature search was conducted using PubMed, ProQuest, and the Cochrane Library following PRISMA guidelines. Keywords included "effectiveness," "hepatitis B," "HBV," "HepB," "vaccine," "vaccination," "immunization," "immune memory," "seroprotection," and "birth dose." Of 555 articles initially identified, nine met the inclusion criteria. Results showed that the duration of protection after primary vaccination ranges from 5 to 25 years, with an average seroprotection rate of 83.5%. Vaccination is vital for newborns, regardless of maternal HBV status, and healthcare professionals play a key role in promoting early immunization. Monitoring anti-HBs antibody levels is also recommended to assess the need for booster doses, which may help prevent HBV transmission and further reduce morbidity and mortality. Show less...

Neonatal immunization programs Birth-dose policy evaluation Long-term serological response Vaccine-induced immune memory

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Nur Cholis Endriyatno, Lina Aliyanti Nurhidayat. Photoprotective Cream Containing Brown Seaweed (Sargassum Sp.) Extract: Optimization By Simplex Lattice Design. Sciences of Pharmacy. 2025; 4(3):109-116.

Abstract: Sunlight containing ultraviolet (UV) rays is harmful to human skin health. Sunscreen is one of the trendy and attractive cosmetics. Brown seaweed extract (Sargassum sp.) has the potential to be developed into a sunscreen product. This study aimed to optimize the formula of a cream containing brown s Show more...

Abstract: Sunlight containing ultraviolet (UV) rays is harmful to human skin health. Sunscreen is one of the trendy and attractive cosmetics. Brown seaweed extract (Sargassum sp.) has the potential to be developed into a sunscreen product. This study aimed to optimize the formula of a cream containing brown seaweed extract and its in vitro photoprotection. A simplex lattice design approach was used to factor (triethanolamine and stearic acid) and responses (pH, viscosity, adhesiveness, and spreadability). The concentration of variation in stearic acid and triethanolamine affects the parameters of pH response, viscosity, adhesion, and spreadability. The simplex lattice design predicts the optimal formula with stearic acid (17%) and triethanolamine (4%). The verification proved that no significant difference between the predicted and actual results. The in vitro photoprotective evaluation results indicate that the brown seaweed extract cream is categorized as providing high sun protection and serving as a sunblock. Optimization of the brown seaweed extract cream formula using stearic acid and triethanolamine factors has been successfully achieved. The conclusion is that brown seaweed extract cream has the potential to be developed into a sunscreen cosmetic. Show less...

Natural photoprotection formulation Triethanolamine emulsifier interaction Brown algae secondary metabolite In vitro cosmetic product

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Yusransyah Yusransyah, Sofi Nurmay Stiani, Farahdina Chairani, Syilvi Adini, Mohamad Subchan, Ferdiyansyah Ferdiyansyah, Nabila Septiani Putri, Rossi Pratiwi, Baha Udin. Effectiveness of TB-Reminder Application in Improving Medication Adherence and Quality of Life of Lung Tuberculosis Patients in Indonesia. Sciences of Pharmacy. 2025; 4(3):117-126.

Abstract: Poor adherence to anti-tuberculosis (TB) treatment continues to hinder therapeutic success and patient quality of life. This study aimed to evaluate the effectiveness of the TB-R mobile application in improving medication adherence and quality of life among pulmonary TB patients at Pandeglang Region Show more...

Abstract: Poor adherence to anti-tuberculosis (TB) treatment continues to hinder therapeutic success and patient quality of life. This study aimed to evaluate the effectiveness of the TB-R mobile application in improving medication adherence and quality of life among pulmonary TB patients at Pandeglang Regional Hospital. Eighty-six patients were randomized into intervention (n = 43) and control (n = 43) groups. Adherence and quality of life were measured using the Medication Adherence Rating Scale (MARS) and EQ-5D-5L, respectively. After one month, the intervention group demonstrated significantly higher adherence (97.7% vs. 79.0%, p < 0.001) and improvement in mean MARS scores (24.7 vs. 22.7, p < 0.001). Although quality of life gains were not statistically significant overall, notable improvements were observed in anxiety/depression and self-care domains. Demographic factors influenced outcomes: patients aged 29–39 and those living with others showed better adherence, while patients aged 40–50 experienced greater quality of life gains. Women aged 51–60 living alone had decreased adherence despite quality of life improvements. These results suggest that mHealth tools like TB-R can enhance adherence, especially when supported by favorable social and demographic conditions. Tailored digital interventions may optimize treatment outcomes in TB care. Future mHealth app development should consider these social and demographic factors to maximize effectiveness and user engagement. Show less...

Mobile health intervention TB Android app for TB treatment EQ-5D-5L in TB care MARS adherence tool TB

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