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English (International)

Impact of Preparation Method in Co-Amorphous System

Home>Article>10.58920/sciphar01010041

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Impact of Preparation Method in Co-Amorphous System

Sciences of Pharmacy

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Impact of Preparation Method in Co-Amorphous System

Outline

Impact of Preparation Method in Co-Amorphous System

Type of Co-Amorphous Preparation Method

Melt and Quench Cooling

Dry Ball Milling

Solvent Evaporation Method

Freeze Dried and Spray Drying Method

OPINION

Amelia Soyata^★, Kenti Kenti, Meylani Sutoro, Novaliana Devianti Sagita

Academic Editor: Angi Nadya Bestari

Sciences of Pharmacy|Vol. 1, Issue 1, pp. 34-40 (2022)

10.58920/sciphar01010041 Creative Commons CC BY 4.0

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Received
May 20, 2022
Revised
Jun 20, 2022
Accepted
Jun 24, 2022
Published
Jun 28, 2022

Abstract

The co-amorphous solid dispersion system is one of the methods to improve the physicochemical characteristics and stability of a drug. With the appropriate material ratio and preparation method, a co-amorphous solid dispersion system can increase the bioavailability of the drug due to an increase in solubility. In addition, the co-amorphous system will maintain its amorphous shape longer than a single compound. However, using unsuitable materials and methods for co-amorphous fabrication will precipitate them and diminish their bioavailability. As a result, exploring the fundamentals of co-amorphous manufacturing methods is essential. This article discusses the physicochemical properties and solubility of co-amorphous mixtures prepared by solvent evaporation, milling, and quenching methods. Scopus, PubMed, and Google Scholar literature were obtained using the keywords 'co-amorphous preparation', 'co-amorphous method', 'solvent evaporation for co-amorphous preparation', 'milling methods for co-amorphous preparation', and 'quenching method for co-amorphous preparation'. We excluded literature whose application was not in the medical field. Based on the findings, the co-amorphous preparation methods have their respective advantages and disadvantages. Solvent evaporation can only be used on a small scale. Milling techniques are laborious and time-consuming but have a large yield and less chemical destruction, while the quenching method is only intended for thermostable compounds.

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