Sciences of Pharmacy Archives (Volume 4 Issue 4)

Mohamad Aprianto Paneo, Teti Sutriyati Tuloli, Moh Rivai Nakoe, Nikmasari Pakaya, Nurain Thomas, Rifka Anggraini Anggai, Multiani S. Latif. Web-Based Pharmacoinformatics Platform for Generic Drug Information in Gorontalo, Indonesia. Sciences of Pharmacy. 2025; 4(4):215-223.

Abstract: This study aims to evaluate the effectiveness of a web-based drug information application in providing accessible and reliable drug-related information to the public in Gorontalo Province, Indonesia. A prospective, non-randomized study was conducted with 205 participants from the Gorontalo community Show more...

Abstract: This study aims to evaluate the effectiveness of a web-based drug information application in providing accessible and reliable drug-related information to the public in Gorontalo Province, Indonesia. A prospective, non-randomized study was conducted with 205 participants from the Gorontalo community. Participants completed a structured questionnaire assessing their experience with the "Cari Obatmu" feature on the Ikatan Apoteker Indonesia (IAI) Gorontalo website. The questionnaire covered various aspects such as user interface, search efficiency, clarity of drug indications, side effects, and usability. Descriptive statistics, Cronbach's Alpha for reliability, One-Way ANOVA for demographic differences, and effect size analysis were used in data analysis. The findings indicated high user satisfaction, with mean scores ranging from 4.16 to 4.28 across different aspects assessed. A Cronbach’s Alpha value of 0.975 confirmed excellent internal consistency of the data. The One-Way ANOVA analysis revealed no significant differences in satisfaction scores among demographic groups (p = 0.636), with effect sizes being minimal. The web-based drug information application was well-received, particularly for its functionality and ease of use. However, further improvements are necessary to enhance user experience and feature development. These findings highlight the potential to expand web-based drug information tools to improve public health outcomes in Indonesia, considering the diverse demographic and user needs. Show less...

Drug Information Web Application User Satisfaction Health Informatics Usability Evaluation

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Made Anindya Ayu Dyavaprathivi, Yustrida Maisa, Ni Made Dwi Sandhiutami. Hair Growth and Antibacterial Effects of Nanoparticle-Based Cosmeceutical Tonic from Pogostemon cablin and Morus alba Leaves. Sciences of Pharmacy. 2025; 4(4):224-230.

Abstract: Hair loss affects a substantial portion of the global population, regardless of age or gender. One effective strategy to address this problem is the use of hair tonics that stimulate hair follicle activity and promote hair growth. This study developed an innovative cosmeceutical nanoparticle-based h Show more...

Abstract: Hair loss affects a substantial portion of the global population, regardless of age or gender. One effective strategy to address this problem is the use of hair tonics that stimulate hair follicle activity and promote hair growth. This study developed an innovative cosmeceutical nanoparticle-based hair tonic combining Nilam and Mulberry leaf extracts, termed nanoNilamBerry. The formulation was prepared using the ionic gelation method and evaluated on rabbits over 28 days by assessing hair length, growth rate, and hair weight. The nanoNilamBerry formulation fulfilled the physicochemical requirements of a nanoparticle system and demonstrated good stability at 4 °C, 25 °C, and 40 °C for up to 28 days. In antibacterial assays against Staphylococcus epidermidis, the Nilam–Mulberry extract produced an inhibition zone of 16.36 ± 0.35 mm, while nanoNilamBerry exhibited a larger zone of 18.4 ± 0.30 mm. The hair tonic formulation showed no signs of skin irritation. The nanoNilamBerry treatment resulted in a hair growth rate of 0.13 ± 0.03 cm/day and a final hair weight of 32.36 mg, compared to 0.09 ± 0.01 cm/day and 27.3 ± 0.31 mg for the simple Nilam–Mulberry extract. Overall, the nanoNilamBerry hair tonic demonstrated superior efficacy, promoting hair growth 3.04 times faster than the untreated control and 1.45 times faster than the non-nano extract combination. These findings indicate that nanoNilamBerry not only provides effective antibacterial protection but also significantly enhances hair follicle stimulation and growth performance. Show less...

Antibacterial Hair tonic Hair growth Mulberry leaf Nanoparticles Nilam leaf

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Yani Mulyani, Marita Kaniawati, Widhya Aligita, Eka Rahmat Nugraha. Ethyl Acetate Fraction of Gynura procumbens Mitigates Hyperglycemia, Dyslipidemia, and Tissue Damage in Streptozotocin-Induced Diabetic Rats. Sciences of Pharmacy. 2025; 4(4):231-238.

Abstract: Dyslipidemia is a lipid metabolism disorder frequently associated with diabetes mellitus and known to increase cardiovascular risk. Although Gynura procumbens has been reported to possess antidiabetic and antidyslipidemic properties, studies focusing on the specific effects of its ethyl acetate frac Show more...

Abstract: Dyslipidemia is a lipid metabolism disorder frequently associated with diabetes mellitus and known to increase cardiovascular risk. Although Gynura procumbens has been reported to possess antidiabetic and antidyslipidemic properties, studies focusing on the specific effects of its ethyl acetate fraction remain limited. This study investigated the therapeutic potential of the ethyl acetate fraction of ethanol extract from G. procumbens in streptozotocin-induced diabetic rats, particularly its impact on blood glucose, lipid profiles, and histological changes in pancreatic and aortic tissues. Thirty rats were randomly assigned to six groups: normal control, diabetic control, glibenclamide, simvastatin, and extract-treated groups at 100 and 150 mg/kg body weight. After 28 days of treatment, the 150 mg/kg dose significantly reduced blood glucose by 61.3%, total cholesterol by 42.1%, triglycerides by 47.3%, and LDL by 55.0%, while increasing HDL by 6.3% compared to diabetic control (p < 0.05). Histological analysis demonstrated regeneration of pancreatic β-cells and improvement of vascular structure in the aorta. These findings suggest that the ethyl acetate fraction of G. procumbens may serve as a promising natural agent for managing diabetes and dyslipidemia. Show less...

Flavonoid compounds Insulin secretion Lipid metabolism Pancreatic β-cell regeneration Oxidative stress reduction Vascular protection

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Tri Diana Puspita Rini, Savinatunnajah Savinatunnajah, Eka Rosa Yustina, Gisela Amaliah Putri Ramadhany, Putri Aprillia Shafara, Oliffia Rahma. Phytochemical Modulation of Neurotransmitter Systems and Neuroplasticity in Depression and Anxiety: A Mechanistic Review. Sciences of Pharmacy. 2025; 4(4):206-214.

Abstract: Depression and anxiety are among the most prevalent mental health disorders worldwide, contributing substantially to disability and mortality, particularly among young adults aged 15–24 years. Their pathophysiology is closely associated with dysregulation of key neurotransmitters, emphasizing the Show more...

Abstract: Depression and anxiety are among the most prevalent mental health disorders worldwide, contributing substantially to disability and mortality, particularly among young adults aged 15–24 years. Their pathophysiology is closely associated with dysregulation of key neurotransmitters, emphasizing the need for safer and more effective long-term therapeutic strategies. Herbal medicine represents a promising alternative due to its multifaceted bioactivity and lower incidence of adverse effects. This review systematically evaluates bioactive compounds from selected medicinal plants and their modulatory effects on neurotransmitter pathways involved in depression and anxiety. Relevant studies published within the past five years were retrieved from PubMed, Scopus, and ScienceDirect databases, with inclusion criteria encompassing in vitro and in vivo investigations of phytochemical actions on neurotransmitter systems. The analysis revealed that plants such as Melissa officinalis (lemon balm), Mimosa pudica, Senna alexandrina, Helianthus annuus, Rosa spp., Laurus nobilis, Mentha piperita, Citrus reticulata, Centella asiatica, Chamaemelum nobile, and Ginkgo biloba exhibit significant antidepressant and anxiolytic properties through modulation of monoaminergic transmission, regulation of the hypothalamic–pituitary–adrenal (HPA) axis, and enhancement of neuroplasticity. These plants also demonstrate antioxidant, anti-inflammatory, and neuroprotective activities that further support their therapeutic potential. In conclusion, herbal-based interventions may serve as valuable complementary approaches for managing depression and anxiety. Nevertheless, well-designed clinical studies are essential to validate their efficacy, safety, and mechanisms in long-term use. Show less...

Neurotransmitter modulation Monoamine oxidase inhibition GABAergic system HPA axis regulation Neuroplasticity enhancement Phytopharmacology

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Satyajit Pandurang Kulkarni, Pritam Chugule, Pallavi Satyajit Kulkarni. Notice of RETRACTION: Randomized Open Clinical Trial to Evaluate Netratarpana Efficacy in Elderly Patients with Primary Insomnia (Anidra). Sciences of Pharmacy. 2025; 4(4):205-205.

Abstract: This article has been retracted due to non-compliance with the journal’s Clinical Trial Registration Policy. The study reported a clinical trial that was not registered in a WHO-recognized public registry, as required by international standards (ICMJE, WHO, COPE). Although the author sought retros Show more...

Abstract: This article has been retracted due to non-compliance with the journal’s Clinical Trial Registration Policy. The study reported a clinical trial that was not registered in a WHO-recognized public registry, as required by international standards (ICMJE, WHO, COPE). Although the author sought retrospective registration, no confirmation was provided within the required timeframe. The editors apologize for not identifying this issue before publication. Show less...

Retracted

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